Exogen
Exogen is a novel nano vector (ranging in size from 50 to 150 nanometers) of human umbilical cord derived exosomes. This vector carries diverse types of nucleic acids and their derivatives (messenger-RNA, micro-RNA), lipids and proteins. They function as a communication network in the body, facilitating signaling between cells, transporting materials and contributing to promote healing, minimize inflammation and improve tissue regeneration.
The contents (cargo) and effects of exosomes vary depending on the properties of the originating cell and manufacturing protocol. Exogen is generated from fetal mesenchymal stem cells by using 2-step purification method to achieve maximum purity of exosome with high content of biomolecules which carry biological important factors implicated in the protection, immunomodulation, regeneration and angiogenesis of damaged tissues.
Exogen production is a complex and meticulous process that typically spans 1-2 weeks and necessitates specific laboratory conditions.
Umbilical cord-derived mesenchymal stem cells are cultured and expanded in a cGMP (current Good Manufacturing Practices) accreted laboratory using optimized methods.
Once an adequate cell population is attained, the cells undergo stress induction through our unique methodology to stimulate exosome biogenesis.
Production of maximum pure exogen (exosome) by diafiltration method followed by chromatography, which is free from chemical contamination and mechanical stress.
Lyophilized the exogen with injectable cryoprotectant to increase the stability for more than 12 months at specified
Quality Control - ensuring high-quality standards for exosome production is crucial for their safe application [these including Mycoplasma Analysis, Endotoxin Test Analysis, Microbial detection and Gram staining, Flow Cytometry Analysis and NTA (Nanoparticle Tracking Analysis)].
There are several mechanisms by which exosomes can mediate intercellular communication, which are
Exosome IV infusion has demonstrated numerous health-improving effects in clinical trials and practical applications. Some of the most notable benefits include:
1. Tissue Regeneration
Promotes tissue repair in musculoskeletal disorders and tissue damage by
delivering essential growth factors, cytokines, and biological compounds,
accelerating the body’s natural healing process.
2. Enhanced Cognitive Function
Improves cognitive performance in patients with neurodegenerative conditions,
stress, or sleep deprivation by reducing neural inflammation and enhancing
neuronal function.
3. Boosted Immune System
Supports immune function by promoting new cell production and reducing damage
from viral or bacterial infections.
4. Improved Skin Health
Enhances collagen production and reduces inflammation, resulting in improved
skin elasticity, firmness, and overall appearance.
5. Reduced Inflammation
Targets underlying inflammatory pathways and suppresses excessive immune
responses associated with chronic inflammation.
6. Faster Recovery
Accelerates recovery from injuries and illnesses by supporting rapid cellular
repair and tissue regeneration.
Exosome IV therapy is typically administered via intravenous infusion (5–100 ml), allowing rapid absorption and faster therapeutic response. Dosage varies based on disease condition and administration route. Exosome dosage is quantified by protein concentration or particle count.
Potential side effects are minimal and similar to standard injections, such as mild redness or bruising at the injection site. As exosomes are not stem cells, the risk of immune rejection is minimal.